Its a cool technology. I had a friend working on using expansion microscopy for neuron connectomics research. Apparently the route the lab was taking was introducing mutations to mouse brains that would cause protein expression that would physically color individual neurons at random, then using an optical microscope to view and trace neurons through an expanded sample.
Its a cool technology. I had a friend working on using expansion microscopy for neuron connectomics research. Apparently the route the lab was taking was introducing mutations to mouse brains that would cause protein expression that would physically color individual neurons at random, then using an optical microscope to view and trace neurons through an expanded sample.
E11 bio recently released https://www.biorxiv.org/content/10.1101/2025.09.26.678648v1....
There’s an animated version at https://www.e11.bio/ and the dataset is publicly available: https://aws.amazon.com/blogs/publicsector/unlocking-the-brai...
That’s a big data application of expansion microscopy. I really enjoyed the charming smaller scale examples in the article.
yes, E11 was the lab I was referring to :)